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gene exp prrx1 mm00440932 m1  (Thermo Fisher)
94
Thermo Fisher gene exp prrx1 mm00440932 m1
Gene Exp Prrx1 Mm00440932 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prrx1 cre mice  (Jackson Laboratory)
90
Jackson Laboratory prrx1 cre mice
a–c Representative μCT reconstructive images of male Ripk4 fl/fl and <t>Prrx1</t> Cre Ripk4 fl/fl mice femur at 16 weeks ( a ) and trabecular microstructural parameters (BMD, BV/TV, Tb.N, Tb.Sp and Tb.Th) ( b ) and cortical microstructural parameters (Ct.Th and Ct.Po) ( c ) derived from μCT analysis ( n = 6 per group), demonstrating significant bone loss after osteolineage RIPK4 ablation. d– f Goldner trichrome staining of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( d ) and histomorphometry analysis of BV/TV, Tb.N ( e ), N.Ob/BS and OS/BS ( f ) ( n = 3 per group). Scale bar, 20 µm. g , h Representative images of calcein double labeling of the mineral layers of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( g ) and histomorphometry analysis of the BFR/BS, MAR, and MS/BS ( h ) ( n = 4 per group). Scale bar, 50 µm. i , j ALP staining ( i ) and alizarin red staining ( j ) of in vitro osteogenesis from Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice. Scale bar, 250 µm. k qPCR analysis of the expression of osteoblast signature genes at the mRNA level between Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice ( n = 3 per group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test (BMD, BV/TV, Tb.N, Tb.Sp of ( b , c ), BV/TV of ( e , f ), MAR of ( h ), Alpl , Bglap , Col1a1 , Sp7 , Runx2 of ( k )), unpaired two-tailed Student’s t test with Welch’s correction (Tb.N of ( e ), MS/BS, BFR/BS of ( h )), and Mann–Whitney U test (Tb.Th of ( b ), Spp1 of ( k )). Source data are provided as a file.
Prrx1 Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/prrx1 cre mice/product/Jackson Laboratory
Average 90 stars, based on 1 article reviews
prrx1 cre mice - by Bioz Stars, 2026-02
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prrx1-cre mice  (Jackson Laboratory)
90
Jackson Laboratory prrx1-cre mice
a–c Representative μCT reconstructive images of male Ripk4 fl/fl and <t>Prrx1</t> Cre Ripk4 fl/fl mice femur at 16 weeks ( a ) and trabecular microstructural parameters (BMD, BV/TV, Tb.N, Tb.Sp and Tb.Th) ( b ) and cortical microstructural parameters (Ct.Th and Ct.Po) ( c ) derived from μCT analysis ( n = 6 per group), demonstrating significant bone loss after osteolineage RIPK4 ablation. d– f Goldner trichrome staining of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( d ) and histomorphometry analysis of BV/TV, Tb.N ( e ), N.Ob/BS and OS/BS ( f ) ( n = 3 per group). Scale bar, 20 µm. g , h Representative images of calcein double labeling of the mineral layers of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( g ) and histomorphometry analysis of the BFR/BS, MAR, and MS/BS ( h ) ( n = 4 per group). Scale bar, 50 µm. i , j ALP staining ( i ) and alizarin red staining ( j ) of in vitro osteogenesis from Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice. Scale bar, 250 µm. k qPCR analysis of the expression of osteoblast signature genes at the mRNA level between Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice ( n = 3 per group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test (BMD, BV/TV, Tb.N, Tb.Sp of ( b , c ), BV/TV of ( e , f ), MAR of ( h ), Alpl , Bglap , Col1a1 , Sp7 , Runx2 of ( k )), unpaired two-tailed Student’s t test with Welch’s correction (Tb.N of ( e ), MS/BS, BFR/BS of ( h )), and Mann–Whitney U test (Tb.Th of ( b ), Spp1 of ( k )). Source data are provided as a file.
Prrx1 Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/prrx1-cre mice/product/Jackson Laboratory
Average 90 stars, based on 1 article reviews
prrx1-cre mice - by Bioz Stars, 2026-02
90/100 stars
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gene exp prrx1 hs00246567 m1  (Thermo Fisher)
94
Thermo Fisher gene exp prrx1 hs00246567 m1
a–c Representative μCT reconstructive images of male Ripk4 fl/fl and <t>Prrx1</t> Cre Ripk4 fl/fl mice femur at 16 weeks ( a ) and trabecular microstructural parameters (BMD, BV/TV, Tb.N, Tb.Sp and Tb.Th) ( b ) and cortical microstructural parameters (Ct.Th and Ct.Po) ( c ) derived from μCT analysis ( n = 6 per group), demonstrating significant bone loss after osteolineage RIPK4 ablation. d– f Goldner trichrome staining of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( d ) and histomorphometry analysis of BV/TV, Tb.N ( e ), N.Ob/BS and OS/BS ( f ) ( n = 3 per group). Scale bar, 20 µm. g , h Representative images of calcein double labeling of the mineral layers of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( g ) and histomorphometry analysis of the BFR/BS, MAR, and MS/BS ( h ) ( n = 4 per group). Scale bar, 50 µm. i , j ALP staining ( i ) and alizarin red staining ( j ) of in vitro osteogenesis from Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice. Scale bar, 250 µm. k qPCR analysis of the expression of osteoblast signature genes at the mRNA level between Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice ( n = 3 per group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test (BMD, BV/TV, Tb.N, Tb.Sp of ( b , c ), BV/TV of ( e , f ), MAR of ( h ), Alpl , Bglap , Col1a1 , Sp7 , Runx2 of ( k )), unpaired two-tailed Student’s t test with Welch’s correction (Tb.N of ( e ), MS/BS, BFR/BS of ( h )), and Mann–Whitney U test (Tb.Th of ( b ), Spp1 of ( k )). Source data are provided as a file.
Gene Exp Prrx1 Hs00246567 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gene exp prrx1 hs00246567 m1/product/Thermo Fisher
Average 94 stars, based on 1 article reviews
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prrx1-cre c57bl6/j transgenic mice  (Jackson Laboratory)
90
Jackson Laboratory prrx1-cre c57bl6/j transgenic mice
a–c Representative μCT reconstructive images of male Ripk4 fl/fl and <t>Prrx1</t> Cre Ripk4 fl/fl mice femur at 16 weeks ( a ) and trabecular microstructural parameters (BMD, BV/TV, Tb.N, Tb.Sp and Tb.Th) ( b ) and cortical microstructural parameters (Ct.Th and Ct.Po) ( c ) derived from μCT analysis ( n = 6 per group), demonstrating significant bone loss after osteolineage RIPK4 ablation. d– f Goldner trichrome staining of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( d ) and histomorphometry analysis of BV/TV, Tb.N ( e ), N.Ob/BS and OS/BS ( f ) ( n = 3 per group). Scale bar, 20 µm. g , h Representative images of calcein double labeling of the mineral layers of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( g ) and histomorphometry analysis of the BFR/BS, MAR, and MS/BS ( h ) ( n = 4 per group). Scale bar, 50 µm. i , j ALP staining ( i ) and alizarin red staining ( j ) of in vitro osteogenesis from Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice. Scale bar, 250 µm. k qPCR analysis of the expression of osteoblast signature genes at the mRNA level between Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice ( n = 3 per group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test (BMD, BV/TV, Tb.N, Tb.Sp of ( b , c ), BV/TV of ( e , f ), MAR of ( h ), Alpl , Bglap , Col1a1 , Sp7 , Runx2 of ( k )), unpaired two-tailed Student’s t test with Welch’s correction (Tb.N of ( e ), MS/BS, BFR/BS of ( h )), and Mann–Whitney U test (Tb.Th of ( b ), Spp1 of ( k )). Source data are provided as a file.
Prrx1 Cre C57bl6/J Transgenic Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/prrx1-cre c57bl6/j transgenic mice/product/Jackson Laboratory
Average 90 stars, based on 1 article reviews
prrx1-cre c57bl6/j transgenic mice - by Bioz Stars, 2026-02
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Image Search Results


a–c Representative μCT reconstructive images of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( a ) and trabecular microstructural parameters (BMD, BV/TV, Tb.N, Tb.Sp and Tb.Th) ( b ) and cortical microstructural parameters (Ct.Th and Ct.Po) ( c ) derived from μCT analysis ( n = 6 per group), demonstrating significant bone loss after osteolineage RIPK4 ablation. d– f Goldner trichrome staining of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( d ) and histomorphometry analysis of BV/TV, Tb.N ( e ), N.Ob/BS and OS/BS ( f ) ( n = 3 per group). Scale bar, 20 µm. g , h Representative images of calcein double labeling of the mineral layers of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( g ) and histomorphometry analysis of the BFR/BS, MAR, and MS/BS ( h ) ( n = 4 per group). Scale bar, 50 µm. i , j ALP staining ( i ) and alizarin red staining ( j ) of in vitro osteogenesis from Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice. Scale bar, 250 µm. k qPCR analysis of the expression of osteoblast signature genes at the mRNA level between Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice ( n = 3 per group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test (BMD, BV/TV, Tb.N, Tb.Sp of ( b , c ), BV/TV of ( e , f ), MAR of ( h ), Alpl , Bglap , Col1a1 , Sp7 , Runx2 of ( k )), unpaired two-tailed Student’s t test with Welch’s correction (Tb.N of ( e ), MS/BS, BFR/BS of ( h )), and Mann–Whitney U test (Tb.Th of ( b ), Spp1 of ( k )). Source data are provided as a file.

Journal: Nature Communications

Article Title: RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer

doi: 10.1038/s41467-025-61808-9

Figure Lengend Snippet: a–c Representative μCT reconstructive images of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( a ) and trabecular microstructural parameters (BMD, BV/TV, Tb.N, Tb.Sp and Tb.Th) ( b ) and cortical microstructural parameters (Ct.Th and Ct.Po) ( c ) derived from μCT analysis ( n = 6 per group), demonstrating significant bone loss after osteolineage RIPK4 ablation. d– f Goldner trichrome staining of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( d ) and histomorphometry analysis of BV/TV, Tb.N ( e ), N.Ob/BS and OS/BS ( f ) ( n = 3 per group). Scale bar, 20 µm. g , h Representative images of calcein double labeling of the mineral layers of male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur at 16 weeks ( g ) and histomorphometry analysis of the BFR/BS, MAR, and MS/BS ( h ) ( n = 4 per group). Scale bar, 50 µm. i , j ALP staining ( i ) and alizarin red staining ( j ) of in vitro osteogenesis from Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice. Scale bar, 250 µm. k qPCR analysis of the expression of osteoblast signature genes at the mRNA level between Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice ( n = 3 per group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test (BMD, BV/TV, Tb.N, Tb.Sp of ( b , c ), BV/TV of ( e , f ), MAR of ( h ), Alpl , Bglap , Col1a1 , Sp7 , Runx2 of ( k )), unpaired two-tailed Student’s t test with Welch’s correction (Tb.N of ( e ), MS/BS, BFR/BS of ( h )), and Mann–Whitney U test (Tb.Th of ( b ), Spp1 of ( k )). Source data are provided as a file.

Article Snippet: Ubc Cre/ERT2 mice (stock number, 007001), Prrx1 Cre mice (stock number, 005584) MitoDendra +/+ mice (stock number, 018385) and mT/mG mice (stock number, 007676) were acquired from Jackson Laboratory.

Techniques: Derivative Assay, Staining, Labeling, In Vitro, Expressing, Two Tailed Test, MANN-WHITNEY

a Flow cytometry analysis of proportions of LT-HSC and ST-HSC in 16-week-old male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur ( n = 3 per group). b Flow cytometry analysis of proportions of CMP, GMP, and MEP in 16-week-old male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur ( n = 3 per group). c Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes and B220 + lymphoid cells in male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur ( n = 3 per group). d Flow cytometry analysis of proportions of LT-HSC and ST-HSC in16-week-old male Ripk4 fl/fl and Dmp1 Cre Ripk4 fl/fl mice femur ( n = 5 per group). e Flow cytometry analysis of proportions of CMP, GMP and MEP in16-week-old male Ripk4 fl/fl and Dmp1 Cre Ripk4 fl/fl mice femur ( n = 5 per group). f Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes and B220 + lymphoid cells in 16-week-old male Ripk4 fl/fl and Dmp1 Cre Ripk4 fl/fl mice femur ( n = 5 per group). g Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes, neutrophils and B220 + lymphoid cells in16-week-old male Ripk4 fl/fl and Lyz2 Cre Ripk4 fl/fl mice femur ( n = 3 per group). h Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes, neutrophils and B220 + lymphoid cells in 16-week-old male Ripk4 fl/fl and Cd4 Cre Ripk4 fl/fl mice femur s ( n = 4 in Ripk4 fl/fl group and n = 3 in Cd4 Cre Ripk4 fl/fl group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test ( a , b , c , CMP, MEP of e , f , g ), unpaired two-tailed Student’s t test with Welch’s correction (GMP of e , h ), and Mann-Whitney U test ( d , g ). Source data are provided as a file.

Journal: Nature Communications

Article Title: RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer

doi: 10.1038/s41467-025-61808-9

Figure Lengend Snippet: a Flow cytometry analysis of proportions of LT-HSC and ST-HSC in 16-week-old male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur ( n = 3 per group). b Flow cytometry analysis of proportions of CMP, GMP, and MEP in 16-week-old male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur ( n = 3 per group). c Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes and B220 + lymphoid cells in male Ripk4 fl/fl and Prrx1 Cre Ripk4 fl/fl mice femur ( n = 3 per group). d Flow cytometry analysis of proportions of LT-HSC and ST-HSC in16-week-old male Ripk4 fl/fl and Dmp1 Cre Ripk4 fl/fl mice femur ( n = 5 per group). e Flow cytometry analysis of proportions of CMP, GMP and MEP in16-week-old male Ripk4 fl/fl and Dmp1 Cre Ripk4 fl/fl mice femur ( n = 5 per group). f Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes and B220 + lymphoid cells in 16-week-old male Ripk4 fl/fl and Dmp1 Cre Ripk4 fl/fl mice femur ( n = 5 per group). g Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes, neutrophils and B220 + lymphoid cells in16-week-old male Ripk4 fl/fl and Lyz2 Cre Ripk4 fl/fl mice femur ( n = 3 per group). h Flow cytometry analysis of proportions of CD11b + myeloid cells, monocytes, neutrophils and B220 + lymphoid cells in 16-week-old male Ripk4 fl/fl and Cd4 Cre Ripk4 fl/fl mice femur s ( n = 4 in Ripk4 fl/fl group and n = 3 in Cd4 Cre Ripk4 fl/fl group). Data are presented as mean ± s.d., with biologically individual data points shown. P values were determined by unpaired two-tailed Student’s t -test ( a , b , c , CMP, MEP of e , f , g ), unpaired two-tailed Student’s t test with Welch’s correction (GMP of e , h ), and Mann-Whitney U test ( d , g ). Source data are provided as a file.

Article Snippet: Ubc Cre/ERT2 mice (stock number, 007001), Prrx1 Cre mice (stock number, 005584) MitoDendra +/+ mice (stock number, 018385) and mT/mG mice (stock number, 007676) were acquired from Jackson Laboratory.

Techniques: Flow Cytometry, Two Tailed Test, MANN-WHITNEY